abstract：BACKGROUND:Congenital malformations are a leading cause of infant mortality in the United States, and risk for some congenital malformations varies by socioeconomic status (SES). Medicaid provides health insurance for people with low income, and covers approximately half of all live births in the United States. Income ...

journal_title：Birth defects research

authors： Richardson SD,Josberger RE

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:The aim of this study is to evaluate the association of TGFA TaqI polymorphism with nonsyndromic cleft lip and/or palate (NSCLP) in an Iranian population. METHODS:In this case-control study, 113 children with NSCLP and 209 controls were included. Genotyping of the TaqI polymorphism was performed by polymera...

journal_title：Birth defects research

authors： Bagheri F,Ebadifar A,Khorram Khorshid HR,Kamali K

更新日期：2017-10-16 00:00:00

abstract：BACKGROUND:The different mechanisms leading to a solitary kidney should be differentiated because the long-term outcome might be different. The fetal period is the best moment to make a true diagnosis of congenital unilateral renal agenesis (URA). The objective was to determine the prevalence of URA at birth. The secon...

journal_title：Birth defects research

authors： Laurichesse Delmas H,Kohler M,Doray B,Lémery D,Francannet C,Quistrebert J,Marie C,Perthus I

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:Quaternary ammonium compounds are a large class of chemicals used for their antimicrobial and antistatic properties. Two common quaternary ammonium compounds, alkyldimethylbenzyl ammonium chloride (ADBAC) and didecyldimethyl ammonium chloride (DDAC), are combined in common cleaners and disinfectants. Introdu...

journal_title：Birth defects research

authors： Hrubec TC,Melin VE,Shea CS,Ferguson EE,Garofola C,Repine CM,Chapman TW,Patel HR,Razvi RM,Sugrue JE,Potineni H,Magnin-Bissel G,Hunt PA

更新日期：2017-08-15 00:00:00

abstract：:The World Health Organization currently recommends quinine+clindamycin for use against malaria in the first trimester. This may soon change to recommending artemisinin-based combination therapies (standard duration of dosing = 3 days). The non-artemisinin partner drugs include amodiaquine, lumefantrine, mefloquine, pi...

journal_title：Birth defects research

authors： Clark RL

更新日期：2017-08-15 00:00:00

abstract：BACKGROUND:Breastfeeding women who are prescribed with psychotropic medications on a regular basis are often concerned, regarding the possible implications of such treatment on the breastfed infant. A mother's well-being has a direct influence on the well-being of the baby. However, the notorious reputation of psychotr...

journal_title：Birth defects research

authors： Kronenfeld N,Berlin M,Shaniv D,Berkovitch M

更新日期：2017-07-17 00:00:00

abstract：BACKGROUND:The acronym VATER/VACTERL refers to the rare nonrandom association of the following component features (CF): vertebral defects (V), anorectal malformations (A), cardiac defects (C), tracheoesophageal fistula with or without esophageal atresia, renal malformations (R), and limb defects (L). Patients presentin...

journal_title：Birth defects research

authors： Zhang R,Marsch F,Kause F,Degenhardt F,Schmiedeke E,Märzheuser S,Hoppe B,Bachour H,Boemers TM,Schäfer M,Spychalski N,Neser J,Leonhardt J,Kosch F,Ure B,Gómez B,Lacher M,Deffaa OJ,Palta M,Wittekindt B,Kleine K,Schm

更新日期：2017-07-17 00:00:00

abstract：:Mouse models are invaluable for investigating the developmental etiology and molecular pathogenesis of structural birth defects. While this has been deployed for studying a wide spectrum of birth defects, mice are particularly valuable for modeling congenital heart disease, given they have the same four-chamber cardia...

journal_title：Birth defects research

authors： Liu X,Kim AJ,Reynolds W,Wu Y,Lo CW

更新日期：2017-06-01 00:00:00

abstract：:Small animal models, particularly mouse models, of human diseases are becoming an indispensable tool for biomedical research. Studies in animal models have provided important insights into the etiology of diseases and accelerated the development of therapeutic strategies. Detailed phenotypic characterization is essent...

journal_title：Birth defects research

authors： Wu YL,Lo CW

更新日期：2017-06-01 00:00:00

abstract：:Neonatal cataracts remain the most common cause of visual loss in children worldwide and have diverse, often unknown, etiologies. This review summarizes current knowledge about the detection, treatment, genetics, risk factors, and molecular mechanisms of congenital cataracts. We emphasize significant progress and topi...

journal_title：Birth defects research

authors： Li J,Xia CH,Wang E,Yao K,Gong X

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Neural tube defects (NTDs) are severe congenital malformations. Folate supplementation can reduce the risk, but cannot prevent all NTDs, suggesting other reasons for folate-resistant NTDs. The present study assesses placental fatty acid composition, eicosanoids, and cytokines as risk factors for NTDs in a Ch...

journal_title：Birth defects research

authors： Li K,Zhang X,Pei L,Chen G,Liu J,Wahlqvist ML,Zheng X,Li D

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Developmental exposure to brominated flame retardants (BFRs), including polybrominated diphenyl ethers (PBDEs) and hexabromocyclododecane (HBCDD), has been associated with impaired neurodevelopment and some symptoms of metabolic syndrome. However, there are inconsistencies in studies reporting neurodevelopme...

journal_title：Birth defects research

authors： Tung EWY,Kawata A,Rigden M,Bowers WJ,Caldwell D,Holloway AC,Robaire B,Hales BF,Wade MG

更新日期：2017-04-17 00:00:00

abstract：:Cytomegalovirus (CMV) is a DNA herpesvirus that is common worldwide. The two known main sources of primary CMV infection during pregnancy are through sexual activity and contact with young children. Primary infection occurs in approximately 1 to 4% of pregnancies, and is mostly asymptomatic in immunocompetent adults. ...

journal_title：Birth defects research

authors： Davis NL,King CC,Kourtis AP

更新日期：2017-03-15 00:00:00

abstract：:Birth defects are the leading cause of infant death in the United States and among the top causes of pediatric death and hospitalization. Despite the devastating impact of birth defects, we understand little of their etiology impeding progress towards treatment and prevention. Moreover, while surgical interventions ha...

journal_title：Birth defects research

authors： Khokha MK,Mitchell LE,Wallingford JB

更新日期：2017-01-30 00:00:00

abstract：BACKGROUND:Recent advances in genomics methodologies, in particular the availability of next-generation sequencing approaches have made it possible to identify risk loci throughout the genome, in particular the exome. In the current study, we present findings from an exome study conducted in five affected individuals o...

journal_title：Birth defects research

authors： Liu H,Busch T,Eliason S,Anand D,Bullard S,Gowans LJJ,Nidey N,Petrin A,Augustine-Akpan EA,Saadi I,Dunnwald M,Lachke SA,Zhu Y,Adeyemo A,Amendt B,Roscioli T,Cornell R,Murray J,Butali A

更新日期：2017-01-20 00:00:00

abstract：BACKGROUND:Hypoplastic right heart syndrome (HRHS) is a rare congenital defect characterized by underdevelopment of the right heart structures commonly accompanied by an atrial septal defect. Familial HRHS reports suggest genetic factor involvement. We examined the role of copy number variants (CNVs) in HRHS. METHODS:...

journal_title：Birth defects research

authors： Dimopoulos A,Sicko RJ,Kay DM,Rigler SL,Druschel CM,Caggana M,Browne ML,Fan R,Romitti PA,Brody LC,Mills JL

更新日期：2017-01-20 00:00:00